Predo : Uses, Side Effects, Interactions, Dosage and more

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It inhibits chemotaxis and the activity of immune cells as well as the release and effect of mediators of inflammatory and immune reactions, e.g. of lysosomal enzymes, prostaglandins and leucotrienes. Fungal and viral infections of the cornea are particularly prone to develop coincidentally with long-term applications of steroids. The possibility of fungal invasion should be considered in any persistent corneal ulceration where steroid treatment has been used . If during the treatment with Lodotra high levels of physical stress are caused by certain events (accidents, surgical procedure etc.), a temporary dose increase may become necessary. However, it has to be taken into account that the immune response and consequently the success of the vaccination may be impaired with higher doses of glucocorticoids.

Use systemic corticosteroids with caution in the geriatric patient; the risks and benefits of therapy should be considered for any individual patient. The Beers expert panel notes that oral and parenteral corticosteroids may be required for conditions such as exacerbation of chronic obstructive pulmonary disease but should be prescribed in the lowest effective dose and for the shortest possible duration. The federal Omnibus Budget Reconciliation Act regulates medication use in residents of long-term care facilities. According to the OBRA guidelines, the need for continued use of a glucocorticoid, with the exception of topical, ophthalmic, or inhaled formulations, should be documented, along with monitoring for and management of adverse consequences. Intermediate or longer-term use may cause hyperglycemia, psychosis, edema, insomnia, hypertension, osteoporosis, mood lability, or depression.

During the treatment with Lodotra, regular blood pressure checks are required in patients with hypertension that is difficult to control. Long-term use of corticosteroids can have negative effects on growth and development in children. Therefore, it is recommended that latent amebiasis or active amebiasis be ruled out before initiating corticosteroid therapy in any patient who has spent time in the tropics or any patient with unexplained diarrhea.

Depending on the treatment result, the dose can be reduced in steps of 1 mg every weeks to reach the appropriate maintenance dose. When changing over from the standard regimen to Lodotra administered at bedtime , the same dose should be maintained. Following the change-over, the dose may be adjusted according to the clinical situation.

In pediatric patients, the use of oral corticosteroids is usually limited to a few weeks until asthma control is improved and the patient can be stabilized on other, preferred treatments. Special consideration should be given to patients at increased risk of osteoporosis (i.e., postmenopausal women) before initiating corticosteroid therapy and bone density should be monitored in patients on long term corticosteroid therapy. Corticosteroids cause growth retardation in infancy, childhood and adolescence, which may be irreversible, and therefore long-term administration of pharmacological doses should be avoided. If prolonged therapy is necessary, treatment should be limited to the minimum suppression of the hypothalamo-pituitary adrenal axis and growth retardation.

The daily dosage, as well as the time of administration of the drug, must be determined by the doctor. Prednisolone Sodium Phosphate should be administered orally using the measuring cup that comes with the medication. The starting dose of oral Prednisolone Sodium Phosphate may vary from 5 to 60 mL per day depending on the specific disease being treated. The onset and duration of action of prednisolone acetate and sodium phosphate suspensions are dependent on the extent of the local blood supply. As glucocorticoids can produce or aggravate Cushing's syndrome, glucocorticoids should be avoided in patients with Cushing's disease unless when needed to correct hypocortisolism that may occur during use of treatments for the condition.

200 mg/day PO for one week, followed by 80 mg PO given on alternate days for one month has been shown to be effective. For the treatment of acquired hemolytic anemia, erythroblastopenia , or congenital hypoplastic anemia. For the treatment of hematologic disorders with thrombocytopenia including immune thrombocytopenic purpura , or secondary thrombocytopenia. The information provided in Incompatibilities of Preloneis based on data of another medicine with exactly the same composition as the Prelone.

If patient is exposed to measles, prophylaxis with pooled intramuscular immunoglobulin may be indicated. If chickenpox develops, treatment with antiviral agents may be considered. Metabolic clearance of corticosteroids is decreased in hypothyroid patients and increased in hyperthyroid patients.